Aging, which can be defined as the „time-related deterioration of the physiological functions necessary for survival and fertility,“ is a process that most people would like to slow (1Trusted Source).

Some of its leading causes include accumulated cellular damage caused by reactive molecules known as free radicals and the shortening of telomere, which are the structures located at the ends of chromosomes that play an essential role in cellular division (1Trusted Source).

While aging is inevitable, increasing the human lifespan and slowing the aging process has been a focus of scientific research for decades.

Through that research, scientists have identified many substances that have anti-aging properties, many of which can be taken as supplements by those looking for natural ways to decelerate the aging process and prevent age-related disease.

Note that this list is not exhaustive, and many other supplements may also offer anti-aging effects.

Here are 12 supplements with anti-aging properties.

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1. Curcumin

Curcumin — the main active compound in turmeric — has been shown to possess powerful anti-aging properties attributed to its potent antioxidant potential.

Cellular senescence occurs when cells stop dividing. As you age, senescent cells accumulate, which is believed to accelerate aging and disease progression (2Trusted Source, 3Trusted Source).

Research demonstrates that curcumin activates specific proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps delay cellular senescence and promotes longevity (4Trusted Source, 5Trusted Source).

Plus, curcumin has been shown to combat cellular damage and significantly increase fruit flies, roundworms, and mice’s lifespan. This compound has been shown to postpone age-related disease and alleviate age-related symptoms (6Trusted Source, 7Trusted Source).

This may be why turmeric intake has been associated with a reduced risk of age-related mental decline in humans (8Trusted Source).

You can increase your curcumin intake by using turmeric in recipes or taking curcumin supplements.


Curcumin is the main active compound in turmeric. It may slow aging by activating specific proteins and protecting against cellular damage.


Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers and other health conditions like heart disease (9Trusted Source, 10Trusted Source, 11Trusted Source).

Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.

EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK).

It also induces autophagy, the process by which your body removes damaged cellular material (12Trusted Source).

Green tea intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13Trusted Source, 14Trusted Source, 15Trusted Source).

EGCG can be consumed by drinking green tea or taking concentrated supplements.


EGCG is a polyphenol compound concentrated in green tea that may improve mitochondrial function and promote autophagy. Green tea intake has been linked to a reduced risk of all-cause mortality.

3. Collagen

Collagen is promoted as a fountain of youth for its potential to reduce the appearance of skin aging.

It’s an integral component of your skin that helps maintain skin structure. As you age, collagen production slows, leading to collagen loss in the skin that accelerates signs of aging like wrinkles.

Some research suggests that supplementing with collagen may reduce signs of aging, including wrinkles and dry skin.

For example, a 2019 study in 72 women demonstrated that taking a supplement that contained 2.5 grams of collagen — along with several other ingredients, including biotin — per day for 12 weeks significantly improved skin hydration, roughness, and elasticity (16Trusted Source).

Another study in 114 women found that treatment with 2.5 grams of collagen peptides for eight weeks significantly reduced eye wrinkles and increased collagen levels in the skin (17Trusted Source).

Though these results are promising, keep in mind that many collagen studies are funded by companies that manufacture collagen products, which may influence study results.

Many types of collagen supplements are on the market, including powders and capsules.


Collagen is a popular dietary supplement that may help prevent skin aging by boosting collagen levels in your skin.

4. CoQ10

Coenzyme Q10 (CoQ10) is an antioxidant that your body produces. It plays an essential role in energy production and protects against cellular damage (18Trusted Source).

Research suggests that levels of CoQ10 decline as you age, and supplementing with it have been shown to improve certain aspects of health in older individuals.

For example, a study in 443 older adults demonstrated that supplementing with CoQ10 and selenium over four years improved their overall quality of life, reduced hospital visits, and slowed physical and mental performance (19Trusted Source).

CoQ10 supplements help reduce oxidative stress, a condition characterized by an accumulation of free radicals and other reactive molecules that accelerates the aging process and onset of age-related disease (20Trusted Source, 21Trusted Source).

Though CoQ10 shows promise as an anti-aging supplement, more evidence is needed before it can be recommended as a natural way to delay aging.

Be sure to consult a trusted healthcare professional before giving it a try.

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